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Generic Provigil 200 mg
$299.99 – $449.99 Buy Now This product has multiple variants. The options may be chosen on the product page -
Generic Provigil 100 mg
$249.99 – $449.99 Buy Now This product has multiple variants. The options may be chosen on the product page
Provigil is also referred to as a generic medication called Modafinil. It is a prescribed medication to enhance wakefulness in patients with specific sleep disorders. These conditions include experiencing excessive daytime sleepiness such as narcolepsy, OSA, and SWSD. Modafinil acts as a eugeroic, that is, it increases wakefulness without causing stimulation. It does not have any side effects like amphetamines or caffeine.
Modafinil is thought to work by increasing neurotransmitters in the brain, such as dopamine, orexin, and histamine, which mediate wakefulness, alertness, and cognition. Unlike classical stimulants, the abuse potential for modafinil is low and has no known crash effect when its effects have worn off.
Modafinil is usually taken as an oral tablet of 200mg in the morning or at the start of a shift and is effective in managing cases of daytime sleepiness caused by sleep disorders. Despite its effectiveness, it remains a medication that does not cure the underlying cause of sleep disorders. It is sometimes employed off-label for cognitive-enhancing purposes, such as improving focus and attention but raises ethical and health questions.
It’s controlled, because it is a controlled Schedule IV which incidentally does have some possibilities of abuse.
Chemical Composition and Mechanism of Action
Provigil is the name is known as modafinil, a wakefulness-promoting agent mainly used to treat conditions like narcolepsy, sleep apnea, and shift work sleep disorder. Sometimes, it’s prescribed off-label for use in the treatment of such conditions as ADHD and MS-related fatigue.
Chemical Composition
- IUPAC Name: 2-[(Diphenylmethyl)thio]acetamide
- Molecular Formula: C₁₉H₁₉NOS
- Molecular Weight: 273.43 g/mol
Chemical Structure: Modafinil contains a sulfinyl group attached to a phenylmethyl group and an amide moiety. The structure, although much simpler than most CNS stimulants, exerts unique effects on brain chemistry.
Mechanism of Action
The exact mechanism of action of Provigil is unknown; several mechanisms have been proposed, including the following. Provigil is believed to act on several neurotransmitter systems implicated in wakefulness and alertness primarily:
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Dopamine Reuptake Inhibition:
It blocks the dopamine transporter, which prevents the reuptake of dopamine back into the presynaptic neuron. This increases the concentration of dopamine available for transmission across the synapse, and it probably acts to enhance wakefulness.
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Release of Increased Histamine and Orexin (Hypocretin):
Provigil has been shown to act on histaminergic as well as orexinergic systems. Histamine acts as a neurotransmitter enhancing wakefulness, and orexin is a neuropeptide that regulates the onset of sleep and wakefulness. The agonism of orexin receptors by Provigil is believed to induce wakefulness and refrain the individual from sleep.
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Serotonergic and Noradrenergic Modulation:
Serotonin and norepinephrine systems have also been affected by Provigil but less so. It might control the release of these neurotransmitters, thus enhancing the drug’s stimulant-like action, though it is weak in comparison to typical stimulants such as amphetamines.
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Glutamate and GABA Modulation:
However, there is also some evidence that Provigil might modulate the balance of excitatory/inhibitory through the possible facilitation of glutamatergic release, including glutamate release, at least in certain areas in some parts of the brain by activating effects.
What Is Provigil Used For
This medicine is mainly prescribed for a sleeping disorder and extreme sleepiness. Aside from that, most people take this pill as their routine to sustain healthy sleeping habits. Use this pill according to the directions given by your doctor for proper direction. Your doctor will give you the appropriate direction for taking the pills.
Normally a patient can take the medicine through his mouth after taking some food or without taking the food. Take this medication orally once a day preferably in the morning time. Sometimes, doctors provide such instructions where they recommend its division into two doses: one to be consumed during the morning time while another during noon.
Different methods are applied for taking medication appropriately.
- For obstructive sleep apnea: Administer the medication once daily in the morning. You can take this medication with food, or before food.
- For good sleeping habits: You can take this medication before starting your work. This will assist you in concentrating on your work.
Provigil Dosage and Administration
The recommended initial dosage for Provigil is 200 mg a day and given in the morning. The dosages could be varied based on the patient’s response to the treatment and condition. The dose recommended commonly in patients with narcolepsy or OSA is 200 mg per day; for patients with shift work sleep disorder, it could range from 100 to 200 mg taken one hour before the onset of work.
This drug comes in tablet forms and is usually very tolerable by most patients. Its administration, however, does not make up for a good night’s sleep. Anyone who has other medical conditions such as heart disease high blood pressure and psychiatric disorders must take this drug under his or her health care provider’s prescription.
How Long Does Provigil Last
It would last around 10 to 12 hours in most subjects, though this could depend on the individual, the rate of metabolism, and the dose.
Duration of Action:
- Peak Effects: For Provigil, peak plasma levels are seen about 2 to 4 hours after oral administration.
- Half-Life: The half-life of the elimination in healthy adults of Provigil is approximately 12 to 15 hours. This is the time that elapses for the concentration of the drug in the blood to be reduced by half.
Entire Duration:
The wakefulness-promoting and alertness-promoting effects of modafinil are usually most potent for the first couple of hours but last throughout the day, waning late in the afternoon or evening.
Because its half-life is relatively long, modafinil typically is taken once daily in the morning, avoiding effects at night. However, its wake-promoting effect is typically sufficient to permit a person to get through a standard workday or shift if that person suffers from conditions like narcolepsy or shift work sleep disorder.
Variability
- Metabolism: The duration might be influenced by liver functions, age, and others, which may increase the metabolism of modafinil or decrease it to some extent.
- Tolerance: After a long time, some individuals may develop tolerance to the stimulative effects of modafinil, although this is relatively much less compared to other drugs.
If you are taking Provigil, and you want to know how long it will last for you, then the best way is to keep track of your response to the medication and consult with your healthcare provider if it seems to be wearing off too early or lasting longer than you want.
Possible Side Effects Of Provigil
Provigil is not suitable for every human body. Some get affected by common side effects and some are serious. Here are some side effects given below have a look;
- Headache
- Vomiting
- Dizziness
- Nausea
- Depression
- Hallucination
- Mental disturbance
- Mood changes
- Allergic reactions
- Rashes
- Itching
- Swelling
- Trouble breathing
If you are encountering any of the side effects then talk to your doctor immediately. And discuss the solution for the side effects, you are facing.
After consuming Provigil, you can easily get addicted to the Provigil. So take the medicine only for some time, that your doctor has prescribed to you. It should not exceed more than that. If a patient gets addicted to the medicine and wants to leave the medicine, then he or she is unable to withdraw it. Some withdrawal symptoms come into being, which are much worse than the problem.
Precautions & Warning
Some precautions and warnings may guide you to take the right path. Read the following points very carefully;
- Do not increase, reduce, or even stop taking the medicine, without discussing it with the doctor. It may create negative side effects, that you will not tolerate.
- Do not consume alcohol, or any other form of alcoholic drink, along with taking Provigil medicine.
- Use this medicine only by health care provider guidance, and in the legal method.
- Do not ask them to take this medicine, who are having the same symptoms of a sleeping disorder. There may be other reasons or some other disorders for these symptoms. So advise him/her for a proper health check-up.
- This medicine is not to be taken by pregnant women, breastfeeding, or even planning to get pregnant women. This might have adverse effects on the baby too, after the baby’s birth.
- Clear your medical history with your doctor. If you have any genetic disorder, heart attack, high blood pressure, liver, lungs, kidney problems, or any mental disorder then tell about this to your doctor. Don’t hide anything.
Food & Medicine Interaction
Food and medicine interaction is the cause of not working the medicine properly. So, here are some points through which you will be relieved from the interaction issue.
Avoid alcohol. This increases the risk of side effects which can be dangerous and even dangerous to death.
Note down items of food, which are commonly consumed.
If you have any other disease, and taking medicines for that then, write down medicines to your doctor. And show it to your doctor for confirmation.
Frequently Asked Questions For Provigil
Here are some of the commonly asked questions about Provigil, that will help you to collect more information about the Provigil. Have a look;
Are Adderall and Provigil the same?
Adderall and Provigil are not the same. Provigil is especially used to treat the sleeping disorder caused by narcolepsy. Adderall can also be used for narcolepsy, but especially it is used to treat ADHD.
How does Provigil make you feel?
Provigil can change a bad mood to a good mood. And can make you comfortable to keep the focus on the work. This increases the confidence level to a high. The effect of Provigil is almost the same as the euphoria.
Does Provigil give you energy?
Provigil does not give energy, it only boosts the confidence level. And helps to work confidentially for a particular time period.